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Saturday, September 16, 2023

US scapegoats China for fentanyl crisis but illness rooted in decades of painkiller abuse, FDA-pharmacy collusion

https://youtu.be/m3ua4VLNI4U?si=7rGXiiZPVYGN9VZs , https://youtu.be/m3ua4VLNI4U?si=7rGXiiZPVYGN9VZs, 
https://youtu.be/m3ua4VLNI4U


A man sits slumped in a street overrun with drug users in Kensington Philadelphia, on July 19, 2021. Photo: VCG

The US is plagued with a drug abuse problem more acute than any other countries as 12 percent of global drug users come from the North American country, two times higher than the proportion of its population.

Provisional data indicates that nearly 110,000 Americans died of drug overdoses in 2022, the highest of all time, and more than two-thirds of the deaths involved the powerful synthetic opioid fentanyl, as per US Centers for Disease Control and Prevention.

Fentanyl-related deaths among children increased more than 30-fold between 2013 and 2021, the Associated Press reported.

US Commerce Secretary Gina Raimondo, when visiting China in late August, claimed that US hopes to cooperate with China to tackle the rapidly increasing rates of fentanyl overdoses. However, the country simultaneously keeps scapegoating China on the issue, imposing sanctions and filing criminal charges against Chinese enterprises and individuals.

Through an investigation into the US' opioid crisis which reveals the country's legislative and law enforcement failures over the decades, the Global Times found that the US is disinclined to find a radical cure, while scapegoating China as a conduit for mounting anger in American society. All this serves the US' strategic rivalry with China.

Painkiller becomes source of pain

There is nothing new under the sun, and the US' fentanyl crisis is a continuation of its forbearer Oxycodone, a strong, semi-synthetic opioid used to treat moderate to severe pain.

The Netflix TV drama Painkiller released in 2023, adapted from a book published in 2003, revealed how the pharmaceutical company Purdue Pharma colluded with US medicinal regulators and developed aggressive marketing tactics to promote its brand name product OxyContin, an extended-release form of Oxycodone, as less likely to cause addiction, raking in tens of millions of dollars.

The US Food and Drug Administration (FDA), charged with the responsibility of prescription drug use regulation, gave OxyContin the green light in 1995 even though neither long-term studies nor assessments of its addictive capabilities had been thoroughly conducted.

Two principal FDA reviewers who originally approved Purdue's application both took positions at the company after leaving the agency. In the following two decades, more FDA staffers involved in opioid approvals left the FDA to work for opioid makers, according to the American Medical Association Journal of Ethics.

Purdue offered kickbacks, paid lecturers, and organized free seminar vacations to doctors to incentivize them to prescribe OxyContin, leading to a tenfold increase in prescriptions for less serious pain, from about 670,000 in 1997 to about 6.2 million in 2002.


Suspected fentanyl pills are seized at the Los Angeles International Airport Los Angeles, California, on October 19, 2022. Photo: VCG

As Purdue earned billions of dollars from oxycodone sales, other drug companies took note; when the numerous unnecessary prescriptions were given to chronic pain patients, addiction and overdose deaths soared.

The US' healthcare system also contributed - "Most insurance, especially for poor people, won't pay for anything but a pill," said Judith Feinberg, a professor at West Virginia University with expertise in infectious diseases associated with drug injection.

The US Department of Health and Human Services estimated that about 11 million people in the US consume oxycodone in a non-medical way annually.

Although Purdue was ultimately brought to justice, addicts are not redeemed. The large, ever expanding group of drug dependence, without proper social support and intervention, easily became the victims of new, more powerful drugs - fentanyl, a synthetic opioid which is also FDA-approved and up to 50 and 100 times stronger than heroine and morphine respectively.

Fentanyl, the cheaper to make yet more lethal drug and its close cousins became the biggest drug-related killers in the US in 2016, the Associated Press reported.

The media has reported on how drug users addicted to other substances unknowingly ingest fentanyl, as local dealers sell "traditional" products like cocaine "cut" with fentanyl, or pills containing fentanyl that are "advertised as legitimate prescription drugs."

Incapable legislation, enforcement

With around 4 percent of the world's population, the US consumes 80 percent of the world's opioids.

Why is the US?

The US' drug problem, including the current fentanyl abuse crisis, is deeply rooted in the country's lobbying political structure and ideology, said Zhang Yifei, an associate research fellow at the Institute of American Studies under the Chinese Academy of Social Sciences.

The colossal profits bundle pharmaceutical companies with the FDA, sponsored politicians, academic groups, and the media, making the fentanyl crisis a predictable tragedy in the US that has enriched a few at the expense of many lives lost, Zhang said.

Academic institutions provide "scientific proof," media and think tanks propagate said proof, and drug makers lobby the government - this is a very complete and mature chain, Zhang elaborated, "They have various ways to exchange rights and interests through the 'revolving door' system."

Zhang also pointed to "the pan-liberalism trend in the US, which emphasizes the absolute freedom of individuals."

US governments, be they federal or state, are incapable of exercising effective regulation on many issues, although some of them, like drugs and guns, have endangered the public, Zhang said.

When the public demands for freedom of marijuana use, governments and drug companies "hear" these calls and legalize the drug, milking profits from sales. Even in states where marijuana remains illegal, its use is prevalent and law enforcement efforts to curb use are almost nonexistent.

A Chinese national who used to live in North Carolina, told the Global Times that it is common to see people "getting high" in public in broad daylight when the drug is illegal.

In the same way, only until the fentanyl crisis becomes so critical that the public demands for action to be taken, will the government finally act. The first fentanyl-related act passed in Congress in 2017, four years after lawmakers receiving alert on the drug.


A woman uses a new vending machine in Brooklyn that will disperse fentanyl test strips and naloxone as well as hygiene kits, maxi pads, Vitamin C, and COVID-19 tests for free on June 5, 2023 in New York City. Photo: VCG

When actions are finally taken, they cannot avoid the trap of US' political wrestling.

Lawmakers, during the US' 2023 legislative session, introduced over 600 bills related to fentanyl. However, in a deeply divided country, many of the fentanyl crime laws are notable for attracting bipartisan support, the New York Times reported in June. When Republican-controlled House reviewed a bill on fentanyl trafficking in May, 132 of the 133 vetoes came from Democrats.

Another incongruous approach is the use of "safer" supervised consumption services (SCS) through which people can use pre-obtained drugs "safety" with the support of trained personnel. Funded by public money, it is hard to say whether such facilities can curb overdoses more than treating those with an addiction, not to mention such "legal sites" can mislead youth to believe addiction and drug use are nothing to worry.

Zeng Lidu, a grassroots narcotic control officer in Central China's Hunan Province, told the Global Times that the US approach of control sounds "odd" in China, which, as one of the countries with the most effective drug control, closely monitors the maker rather than potential user.

"Fentanyl has variable structures, making it more difficult than the traditional drugs to crack down on," Zeng told the Global Times. "In our district, only a few chemical plants and hospitals are allowed the use of fentanyl under close supervision. We trace and regulate every step in their use, transportation, and storage of fentanyl."

Experts told the Global Times that many fentanyl precursors are widely used in the chemical industry. China, as a chemical giant, does not have a fentanyl abuse problem at home, which says a lot about the root cause of the American drug disease.

Not cooperation but scapegoating

Out of humanitarianism, China is willing to cooperate with the US in tackling the proliferation of fentanyl and has established a cooperation mechanism with the US on the issue.

China scheduled and controlled all fentanyl-related substance by class in 2019 - the first country to do so in the world, while the US itself is yet to do the same. China formulated three legal documents to support the filing, prosecution, conviction, and sentencing of offenses involving these substances. To reinforce fentanyl testing and monitoring, five sub-centers of the National Drug Laboratory have been established across the country.

But the US in 2020 unilaterally and arbitrarily imposed sanctions on the institute of forensic science under China's Ministry of Public Security and National Drug Laboratory, severely jeopardizing related cooperation.

A new vilification of China popular in the US is that Chinese firms sell commonly used chemicals to a third country, such as Mexico, where fentanyl is manufactured and later sold to the US. Citing this, the US has sanctioned Chinese companies, even including tablet press machine makers.

Analysts stressed the "know your customer" practice that some in the US have been asking about far exceeds UN obligations. According to international practices, it is up to the importing country to ensure that imported goods are not used for illegal purposes, not the exporter. China has no sovereign right over a third country, and Chinese companies are not capable of verifying all buyers of its product.

Zhang Yifei said scapegoating China on fentanyl is an easy and convenient approach for the US government to unleash domestic anger against ineffective drug control.

Through distorted coverage on the issue, domestic media outlets successfully sell "China responsible" narrative to Americans at home. By repeatedly hyping the narrative at international occasions, the US also adds fentanyl into its recipe cooking "China threat."

In this sense, fentanyl is essentially same to long-term smear campaign against China on many topics including human rights in Xinjiang region, Zhang said.

As the presidential elections approach, blaming China for its domestic social handicaps as a political tactic sounds ridiculous, but quite a number of US politicians and voters buy this logic, Zhang noted. As the US' domestic political infighting escalates, chance of cooperation on this area which the US is in urgent need of, may narrow even further.

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Friday, September 15, 2023

Blinken sounds a rallying cry for a ‘new cold war’ that US cannot win

 ;How Joe Biden's War with China is Making the USA Weaker

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The growing US' geopolitical competition with Russia and China marks the end of the post-Cold War world order, US Secretary of State Antony Blinken said, speaking at the Johns Hopkins University's School of Advanced International Studies on Wednesday. "What we are experiencing now is more than a test of the post-Cold War order. It's the end of it," he noted. "Decades of relative geopolitical stability have given way to an intensifying competition with authoritarian powers, revisionist powers." This statement appears to be a rallying cry for a "new cold war."

Since the post-Cold War order is coming to an end, what kind of new world order does the US want? Various signs indicate that the US wants major power competition and camp confrontation in order to maintain its global hegemony, even at the expense of the interests of other countries, including allies, and partner nations. However, the reality is that major power competition goes against the trend of the times and cannot solve the US' own problems and the challenges facing the world. It will only further divide the world, leading the world to slide toward a more dangerous cliff edge.

Regarding Blinken's remarks, there are two main points to consider. Firstly, Blinken was creating a sense of crisis in the world. The underlying message to US allies and other countries is that there are challengers, particularly China and Russia, who want to change the existing order. Secondly, Blinken's remarks also reflect a sense of anxiety in the US. The US is attempting to slow down China's rise through strategic competition, while hoping to sustain its hegemony without jeopardizing its own interests. However, it seems that the US has no clear solution to this dilemma.

China is one of the beneficiaries of the existing system and does not seek to challenge or subvert this order. However, the US has viewed any legitimate demand made by China, even those that reflect the reasonable demands of the majority of developing countries, as a challenge and ill-intentioned sabotage.

Xin Qiang, deputy director of the American Studies Center of Fudan University, believes that US irrational crackdown on China will only irritate China and other developing countries. Many developing countries share common demands with China, but the US opposes whatever China proposes and intends to strangle its legitimate right for development. This will ultimately lead to the destruction of the existing international order and be counterproductive to the US' goals.

The US believes that by containing China, it will gain an advantage. However, whatever damage they're doing to China, it also backfires on the US and even the world.

The US now sees China as a competitor and challenger, opposing and obstructing anything that may benefit China, regardless of its impact on the US. This approach not only fails to maintain US hegemony but also leads it further away from the right direction. 

Today, the US is embroiled in simultaneous confrontations with China and Russia. The US needs to think carefully, as it will be more difficult to engage in a "new cold war" compared to the previous one. In the 1970s, the US GDP accounted for nearly one-third of the global total, but now it is only one-fourth. Its two major opponents are the nuclear power Russia and the economic powerhouse China. In order to defeat Russia, the US must ultimately dismantle its nuclear deterrence, which would be a thrilling adventure. 

As for China, the US is attempting to stifle its development by imposing unlimited technological restrictions, but it is unable to completely decouple from China economically. For the US and its main allies, China is either their largest single trading partner or one of the largest. Today, the US is a reckless strategic aggressor, attempting to unite its relatively weaker strength with its allies to wage a new cold war. It should be noted that the power of US allies has declined significantly, and the unity of the "West" is crippled due to the US transitioning from a "blood donor" to a "vampire".

The current generation of American elites arrogantly seeks to replicate the victory of the Cold War, but they will never succeed. Instead, the US will face a different ending.

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Wednesday, September 13, 2023

US Virus-hunting programme shut down due to pandemic fear

 

US shuts controversial $125 mn wildlife virus hunting ...




The idea behind the US virus-hunting programme was to prevent a pandemic, but after Covid-19 emerged, the fear of it accidentally triggering one instead became too real to ignore. — Freepik

For more than a decade, the US government has been funding international programmes engaged in identifying exotic wildlife viruses that might someday infect humans.

But The BMJ revealed on Sept 7 (2023) that a flagship project for hunting viruses among wildlife in South-East Asia, Africa and Latin America to prevent human outbreaks and pandemics is being quietly dropped by the United States Agency for International Development (USAID) after private and bipartisan criticism over the safety of such research.

The shuttering of the project marks an abrupt retreat by the US government from wildlife virus-hunting – an activity that has also been funded by the US Department of Defense and the US National Institutes of Health, reports investigative journalist David Willman.

Risk of a pandemic

The turnabout follows warnings raised by sceptics, including officials within the Biden White House, that the US$125mil (RM584.5mil) DEEP VZN programme could inadvertently ignite a pandemic.

The misgivings continue to resonate now, as the cause of the Covid-19 pandemic – the world’s most deadly such event in a century – remains unproven.

USAID – an arm of the US State Department – launched DEEP VZN (short for Discovery & Exploration of Emerging Pathogens – Viral Zoonoses) in October 2021, succeeding an earlier, decade-long USAID programme called PREDICT, explains Willman.

The agency promoted it as “a critical next step to understand and address the risks posed by zoonotic diseases that can be transmitted from animals to humans”, and said it would help the world “be better prepared to detect, prevent and respond to future biological threats”.

But in July (2023), officials at USAID quietly informed aides to Democratic and Republican members of two US Senate committees with jurisdiction over DEEP VZN that it was being shut down.

This previously-unpublicised decision comes as concerns have heightened over the many risks of working with exotic viruses, including unresolved questions about whether a research mishap or a naturally-occurring spillover of virus from an animal species to humans caused the Covid-19 pandemic.

For instance, in December 2021, two senior White House officials specialising in biosecurity and biosafety – Jason Matheny, deputy assistant to US President Joe Biden for technology and national security, and Daniel Gastfriend, the US National Security Council’s director for biodefence and pandemic preparedness – first privately shared their views with USAID Administrator Samantha Power and advised her to shut down DEEP VZN.

Later, another White House official, Dr T. Gregory McKelvey Jr, a physician and the assistant director for biosecurity with the US Office of Science and Technology Policy, also privately raised concerns with USAID staff.

Power eventually told Matheny and Gastfriend that she would initiate a review of the programme to ensure DEEP VZN could be conducted in a way that adequately managed the risks.

On Sept 6 (2023), USAID said in response to questions from The BMJ, that it had decided to “end the DEEP VZN” project.

The decision, said USAID, reflected “the relative risks and impact of our programming”.

Audit to be done

Matheny, who left the White House in mid-2022 told The BMJ: “It seems likely that the agency assessed that the risks exceeded the benefits of the programme.”

Willman also notes that in May (2023), three leaders of the Republican-controlled US House Energy and Commerce Committee asked the US Government Accountability Office (GAO) to open a scientific audit to “assess the benefits and risks of conducting predictive field research programmes for viruses”.

The US GAO’s acting chief scientist Dr Karen L. Howard estimated in an email to The BMJ that the audit would likely be completed during spring 2024, but declined to discuss any preliminary findings.

Meanwhile, USAID’s funding of the DEEP VZN programme has continued to draw scrutiny behind the scenes from members and staff with both the US Senate Foreign Relations and Senate Appropriations committees, interviews and documents show, writes Willman.

The exchanges between the US Senate and USAID culminated with a brief mention of the previously-unreported termination of DEEP VZN inside the State Department’s fiscal year 2024 appropriation, dated July 20 (2023): “The Committee notes the decision by USAID to cease funding for the exploration of unknown pathogens.”

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Monday, September 11, 2023

Invasive Alien Species (IAS) threats to the environment

 

Threat of invasive alien species is increasing worldwide: International study


Spreading awareness: Azah (centre) inspecting a Jom Kenali IAS exhibit at the National Botanic Gardens Shah Alam. — MUHAMAD SHAHRIL ROSLI/The Star

No, this is not science fiction – IAS refers to animals and plants that are introduced accidentally or deliberately into a natural environment where they are not normally found.

They will adversely affect their new environment, including plants, animals and humans.

Agriculture and Food Security Ministry deputy secretary-general (Policy) Datuk Azah Hanim Ahmad said IAS is the second biggest threat to Malaysia’s biodiversity after habitat fragmentation.

So far, IAS has cost millions of ringgit in losses to the country and its food security sector, she added.

“Some examples of the negative effects of IAS on animals are the Nipah virus, which spread in 1998 (following an outbreak at pig farms in Perak) and Lumpy Skin Disease in 2021 due to imported cows.

“For plants, 465ha of coconut plantations in Terengganu were destroyed by rhynchophorus ferrugineus (kumbang merah palma) in 2007, causing RM10mil in losses.

“And between 2003 and 2006, Papaya Dieback disease damaged over one million papaya trees, causing RM200mil in losses,” she said.Currently, she said, the Bacterial Panicle Blight, an exotic plant pest, is attacking padi fields.

“Parthenium hysterophorus (rumpai parthenium) can cause allergic reactions in humans and farm animals while Salvinia molesta (rumpai salvinia) can affect irrigation systems,” she said at the launch of the ‘2023 Public Awareness Programme: Let’s Get To Know About IAS (Jom Kenali IAS)’ at the National Botanical Gardens Shah Alam yesterday.

Currently, out of the 138 IAS identified worldwide, 64 are present in Malaysia, Azah said.

Of these, 17 are plants, 19 are animals and 28 are aquatic.

She added that due to this threat, the ministry has to continuously inspect and conduct damage control on crops and animals, which costs money and also contributes to pollution.

“This is due to the IAS management team having to use chemical pesticides and cutting down trees, which affects the productivity of the farming sector.

“This is why awareness among the public is important and we hope that today’s programme can make a big impact on the sustainability of the country’s biodiversity,” she said.

To help protect the country’s biodiversity, the government established the National IAS Committee in 2016 to manage, coordinate and prevent all IAS-related issues in Malaysia.

Meanwhile, the ministry’s Fisheries Biosecurity Division senior director Yeo Moi Eim said there are 28 types of aquatic life that have been gazetted and categorised as “prohibited fish species for import into Malaysia”. These include piranha, salmon, trout and dragon fish (arapaima).

She said the department is currently in the process of gazetting the Mekong red tail catfish (baung ekor merah Mekong), which is considered an apex predator in rivers and can weigh up to 40kg, as prohbited for import.

“The Mekong red tail catfish can be found in Perak, Pahang and Selangor rivers. It eats fish and prawns as well as their eggs, and this is harming our marine biodiversity.

“It originates from the Mekong River, but somehow managed to find its way here.

“We believe this was due to natural disasters such as floods where the fish can migrate from one place to another, which shows another impact of climate change,” said Yeo.

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