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Showing posts with label wellness. Show all posts
Showing posts with label wellness. Show all posts

Monday, June 8, 2020

China's Covid-19 vaccine will be available for all, could be ready for public use early next year

China will make its Covid-19 vaccine a global public good when it is ready for application after successful research and clinical trials, a senior Chinese official said.

Finding a cure: An engineer conducting tests on an experimental vaccine for Covid-19 at a laboratory in Beijing

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Wang Zhigang, minister of science and technology, said at a press conference in Beijing yesterday that international cooperation should be strengthened in vaccine development, clinical trials and application.

Vaccine development should focus on ensuring safety, effectiveness and accessibility, he added.


To date, four inactivated vaccines and one adenovirus vaccine had been approved for clinical trials, said a white paper titled “Fighting Covid-19: China in Action”, which was released by the State Council Information Office yesterday.

While scientists in China and abroad had kept up with mutual developments, China led the world in the development of certain types of vaccines, the white paper said.

A great deal of international cooperation had been carried out so far in terms of vaccine development, according to Wang.

Highlighting the significant role that vaccines had played in human history, Wang said both Chinese scientists and those in other countries were trying to make contributions to building a global community of health for all.

He, however, noted that the development of vaccines is a rigorous and complex procedure, which faces many uncertainties and may take a long period of time.

Wang also said drug research and development had been a priority in the efforts of fighting the pandemic in China since the very start, with more than 160 research institutes and enterprises taking part in various programmes.

Meanwhile, Ma Xiaowei, minister of the National Health Commission, said at the press conference that China would strengthen the building of public health emergency response system as the Covid-19 pandemic had exposed flaws in the country’s medical and public health system.

The country would improve the investment mechanism on public health system so that it would be in a better situation to handle disease prevention and control, he said.

Different levels of disease prevention and control centres would have a clearer definition of their functions, with the Chinese Centre for Disease Control and Prevention making the final decision on scientific research, testing, guidance and pathogenic analysis on epidemic diseases, Ma added.

“Moreover, we will further improve the reporting and warning system of major public health incidents by building public opinion monitoring system, reporting system by medical workers and reporting system on scientific findings,” he said.

There would also be new policies in cultivating more talents in public health and improving their treatment, especially talents in pathogenic detection, epidemiological investigation, laboratory testing and analysis on epidemic situation, he added.

China could have Covid-19 vaccine ‘ready for public use early next year’


Three vaccines developed by Chinese companies and researchers are in their second or third phase of trials. - Reuters
  China may have a vaccine against the  deadly Covid-19 for emergency use by September and for the general public early next year, a top Chinese public health expert has said..

This is the first time a Chinese official has put an estimate on the timescale for development of a coronavirus vaccine, believed to be the key to containing the global pandemic. The US Food and Drug Administration believes a vaccine in the United States could be at least a year away, and the World Health Organisation (WHO) has said that it could take 12 to 18 months..

Gao Fu, head of the Chinese Centre for Disease Control and Prevention, on Thursday told China Global Television Network, the overseas arm of the state broadcaster, that vaccines currently at phase two or three of clinical trials could be available by the time of a potential second wave of outbreaks. Three Chinese vaccines have completed the first phase of trials.

“We are in the frontline for the vaccine development, and we may have a vaccine ready for emergency use by September,” Gao said. “These newly developed vaccines, which are still under phase two or phase three clinical trials, could be used for some special groups of people, for example health care workers.”.

https://youtu.be/WsUFEd1_bws br />
Gao added that “we may have a vaccine for the healthy population early next year”, but stressed that its feasibility would depend on “progress of our development”..

Unlike influenza – whose frequent mutations must be anticipated by vaccine makers preparing for seasonal outbreaks – Sars-Cov-2, the virus that causes the disease Covid-19, is believed not to mutate as often and is unlikely to become a “new norm” such as seasonal flu, according to virologist Shi Yi, of the Institute of Microbiology, Chinese Academy of Sciences..

“Some experts believe the epidemical new coronavirus will become a norm and spread like the influenza virus... but [we believe] such probability would be relatively low,” Shi told reporters at a regular briefing in Beijing on Thursday. “At present, there is no evidence that the new coronavirus has the same variability as influenza virus.”.

https://youtu.be/8oQM48rToSc

Shi also rejected the possibility of Covid-19 becoming a chronic illness, given that the virus multiplies mainly in patients’ respiratory tracts and no continuous virus carrying has been observed. He added that the same was true of the century’s two other known coronavirus-induced diseases, severe acute respiratory syndrome (Sars) and Middle East respiratory syndrome (Mers)..

As the coronavirus has swept the globe and infected more than 2.7 million people, causing nearly 200,000 deaths, scientists have raced to develop a vaccine to combat the pandemic. By Thursday, six candidates had entered into clinical trials and 77 others were in preclinical studies, according to the WHO..

https://youtu.be/vfL7DzdNl54

Newly added to the group being trialled was a viral vector vaccine developed by a team of researchers from the University of Oxford, which was injected into its first two volunteers on Thursday and was based on a technology used to develop a vaccine for Mers..

The team’s leader, Dr Sarah Gilbert, reportedly expressed hope that 1 million doses would be ready for use by September.

Trump adviser claims China may be keeping data to win virus vaccine race


US biotech start-up Moderna started the world’s first coronavirus clinical trial in March, on its mRNA vaccine. Another US company, Inovio Pharmaceuticals, kicked off its first human trial of a DNA vaccine last month..

Three vaccines developed by Chinese companies and researchers have passed their first phase of trials for safety and earlier this month started the second phase, involving hundreds to more than 1,000 volunteers testing their effectiveness and researchers assessing vaccination doses..

https://youtu.be/UEzZ6sZegso

The trio included the Adenovirus-vector vaccine, by Tianjin-based Cansino Biological I and Beijing Institute of Biotechnology, and two inactivated vaccines developed by the Wuhan Institute of Biological Products and Sinovac Research & Development in Beijing..

China has experienced an easing of the Covid-19 epidemic after nearly five months of the outbreak, which was first reported in the central city of Wuhan. It reported only four locally transmitted and two imported cases on Thursday, while the number of patients still under treatment has fallen to below 1,700..

Existing drugs ‘may prove effective on coronavirus before vaccine comes’

But vaccines under development will require an effective patient population for the third phase of trials, to allow their effectiveness to be tested in an environment where the virus is still prevalent..

Researchers must overcome difficulties such as “vaccine enhancement”, in which a disease is exacerbated in a vaccinated person infected with the actual virus..

Sign up now now and get a 10% discount (original price US$400) off the China AI Report 2020 by SCMP Research. Learn about the AI ambitions of Alibaba, Baidu & JD.com through our in-depth case studies, and explore new applications of AI across industries. The report also includes exclusive access to webinars to interact with C-level executives from leading China AI companies (via live Q&A sessions). Offer valid until 31 May 2020..

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Covid-19 Recovery countdown Malaysia conditional movement control order will be replaced with recovery movement control order from June 10 to Aug 31, 2020

Activities that are allowed, not allowed and pending during the recovery movement control order period. 

Conditional MCO to be replaced with recovery MCO from June 10 - Aug 31, says PM


Prime Minister Tan Sri Muhyiddin Yassin on Sunday announced that the conditional movement control order will be replaced with recovery movement control order, which will begin from June 10 to Aug 31.

The Prime Minister said that this phase from June 10 to Aug 31 is part of the exit strategy, as Covid-19 cases were under control in Malaysia.



https://youtu.be/Zx_FHZ8eZtk


PM announces 'recovery mode' MCO from June 10, cross-state travel allowed


https://youtu.be/OrUlBvbH6jQ
ALLOWED

• Interstate travel

• Home quarantine for returnees

• Normal business hours

• Domestic tourism • Meetings, workshops

• Recreational fishing<

• Barbers, hair salons, beauty parlours

• Self-service laundrettes

• Museum visits

• Indoor busking

• Cycling

• Motorcycle convoy

• Commercial fishing ponds

• Hari Raya Aidiladha celebration based on SOP

NOT ALLOWED

• Overseas travel

• Pubs, nightclubs, karaoke centres, entertainment outlets, theme parks

• Reflexology centres

• Feasts, open houses

• Spectator sports

• Public swimming pools

• Close-contact sports: rugby, wrestling, boxing, football, basketball, hockey

• Big religious processions

PENDING

• Schools to reopen in stages

• More congregants to pray at mosques based on size of premises

• Sports SOP


More relaxation on public activities



https://www.thestar.com.my/news/nation/2020/06/08/more-relaxation-on-public-activities?jwsource=cl

There will be more relaxation on public activities with the government replacing the conditional movement control order (MCO) with the recovery movement control order from Wednesday.

Prime Minister Tan Sri Muhyiddin Yassin said the new phase, which would take effect from June 10 until Aug 31, was part of an exit strategy after the government successfully contained the spread of Covid-19.

“During the implementation of the recovery MCO, more restrictions will be relaxed to allow the public to carry out their daily activities while complying with the standard operating procedure (SOP), ” the Prime Minister said in a special televised address yesterday.

The MCO was first put in place on March 18 to break the chain of Covid-19 infections.

Muhyiddin explained that statistics from the Health Ministry showed that the infection rate was on the downward trend, remained low and under control.

“Most of the cases recently involved imported cases involving illegal foreign workers in the Immigration depots.

“We are thankful with the swift action taken by our frontliners, who successfully curbed the spread of Covid-19 among the detainees, ” he said.

This is the second phase of easing up on rules after the first round of relaxation under the conditional MCO which began on May 4 and which was later extended to June 9.

Under the recovery MCO, interstate travel has been allowed except for areas placed under enhanced MCO.

“Those who want to visit their parents who are currently living in other states will be able to do so.

“My advice is just to take care of personal hygiene in public places and avoid crowded areas while you are in your hometown.

“Please remember, if your parents are senior citizens, they are in the high-risk category and can be easily infected. So, although we are happy to visit them, it is our main responsibility to protect them from being infected, ” he said.

However, overseas travel is still not permitted as the country’s borders remain shut.

Muhyiddin also pointed out that almost all social, education, religious, business and economic sectors would be operational again in stages with strict adherence to the SOP.

This includes open-air market, morning market, pasar malam (night market), tamu (market), bazaars, food court, food stalls, food trucks and restaurants which have been given the green light.

Muhyiddin also noted that domestic tourism would be allowed and encouraged.

Restrictions on leisure activities, including visiting museums, entertainment and creative outlets will also be eased, while indoor busking and filming will be permitted to operate.

Muhyiddin said the recovery MCO would be implemented based on seven strategies.

They comprise fortifying public healthcare, law and enforcement, strengthening border control, fully reopening the economic sector, inculcating new normal culture, empowering community responsibility and protecting the high-risk group.

Businesses that are still not allowed to operate include pubs, night clubs, entertainment centres, reflexology centres, karaoke centres and theme parks.

Religious gatherings, open houses, and feasts involving large crowd are also not allowed.

He also warned that the government would not hesitate to impose enhanced MCO at localities where a surge in the number of Covid-19 cases was detected.

Therefore, he said people should strictly observe the conditions imposed by the health authorities to reduce the risk of Covid-19 transmission.

Muhyiddin said the public could visit the National Security Council website to get the full list of activities that were allowed and not allowed.

“If all of you are disciplined and remain steadfast, Insya-Allah, it will remain under control.

“We will enter the normalisation period after Aug 31 until a vaccine for Covid-19 is found, ” he said.

He also urged the public to download the MySejahtera mobile application developed by the government to self-assess their own health.

Meanwhile, the Penang government will be holding a state security council committee meeting on Wednesday before implementing the recovery MCO. Bernama reported that the Melaka government was not ready to allow barbershops, hair and beauty salons, the morning open markets, pasar malam as well as bazaars to operate on the date announced by the Federal Government.

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Wednesday, May 27, 2020

WHO praises China’s openness to identify virus source



How the U.S. response to COVID-19 failed and caused thousands of deaths


https://youtu.be/_Geb5l6Ymhw

There have been over 1.6 million #coronavirus cases and nearly 100,000 deaths in the U.S. While many countries are gradually recovering, no turning point for the pandemic in America is on the sight. Lots of people are shocked at how America, the largest economy in the world, and a great country in the eyes of many, has got to this point. So to find out what led to this mess, let's back up a little and take a look at the timeline. Subscribe to us on YouTube: https://goo.gl/lP12gA Download our APP on Apple Store (iOS): https://itunes.apple.com/us/app/cctvn... Download our APP on Google Play (Android): https://play.google.com/store/apps/de...


https://youtu.be/qttzjjMYueg



https://youtu.be/1sRxfbzI19k

 The World Health Organization has praised China's response to the coronavirus outbreak and its efforts to stop it from spreading overseas. 

GENEVA: The World Health Organisation (WHO) said it appreciates China’s openness to joint efforts by the international science community to identify the source of the virus, and that such a scientific mission should consist of “the right mix of scientific experts from a multinational perspective”.

“We’ve been in discussions day-to-day with our colleagues in China about putting together the necessary scientific inquiries into the origin of the virus, ” Dr Michael Ryan, executive director of WHO Health Emergencies Programme, said in a press conference on Monday.

“I think the authorities in China, governments around the world and ourselves are very keen to understand the animal origin of the virus itself. And I am very pleased to hear a very consistent message coming from China, which is one of openness to such an approach, ” he added.

However, he said a date has not been set yet for a scientific mission.

Technical lead of the WHO Health Emergencies Programme, Dr Maria Van Kerkhove, said the organisation has been in regular contact with experts in China.

“We welcome the opportunity to work with them and with the international community, to really understand the virus’ origins and the animal human interface, ” she said.

Meanwhile, Dr Ryan said he was “pleased” to see the publication of the first peer-reviewed journal publications of the vaccine studies from China.

“I think in terms of the number of scientific publications that have come from China over the last number of months is very good and the number of scientific collaborations between Chinese institutions and institutions all over the world is also a very positive sign, ” he said.

On Sunday, Foreign Minister Wang Yi said that China was open to joint efforts by the international science community to identify the source of the virus. — Xinhua

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Wednesday, April 6, 2016

Supersized and overweight civil servants

The public waiting their turn for services at a government department. - Filepic

When those two words describe a nation's public sector, it means it's truly a burden on taxpayers.

POOR civil servants! If you watched Disney’s animated film Zootopia, you would have caught the hilarious scene where the heroes, a rabbit and a fox, rushed to the Department of Motor Vehicles to check out a licence plate, only to get very, very slow service from the sloths manning the counter.

It would appear this stereotyping of civil servants’ work ethic is universal, which is why the parody tickled audiences everywhere.

Now Malaysians have another reason to make fun of their civil servants: they’re too fat. At least the ones in Putrajaya are, according to the 2015 National Health and Morbidity Survey (NHMS) which showed it has the highest rate of overweight and obese citizens.

It’s an established fact that Putrajaya is populated overwhelmingly by government employees, which means those living and serving in the very heart of the nation’s administrative capital are rather unhealthy.

That’s a bummer because, design-wise, Putrajaya got it right. It was a winner in the 75,001­ to 150,000-population category for the Whole City Award under the International Awards for Liveable Communities 2012.

In the paper submitted for the awards, Putrajaya boasted of having “lush greeneries surrounding buildings, infrastructure, (12) parks and gardens.” What’s more, the same paper took into account the need to keep Putra­jaya folks fit and healthy.

It noted that 28% of the residents had a normal BMI (Body Mass Index), 36.3% were overweight, 27.4% obese and 8.3% were even underweight. That was in 2011.

Just four years later, 37% of Putrajayans are said to be overweight and their obesity rate is 43%, according to the NHMS findings.

These are alarming jumps and more so when there were efforts like the Healthy Parks, Healthy People programme to get the residents to exercise to stave off lifestyle diseases like hypertension and diabetes. Among the activities was the Putrajaya Inter-Park Ride monthly cycling event.

So what gives? Why are Putrajayans and Malaysians on the whole so fat? We hold the title of Fatties of South-East Asia; some reports say the whole of Asia.

Some people may, in a perverse way, hail having an overly well-fed population as a sign of a nation’s prosperity. After all, the fattest people in the world are the Americans.

A How’s Life? 2015 Report by the Organisation for Economic Coopera­tion and Development ranked the United States as the nation with the most obese population. It also had the fattest children and the unhealthiest teenagers by a wide margin.

The findings are said to be a blow to the Obama administration and First Lady Michelle Obama because they have been championing this cause for years, including reducing sugar and salt from school lunches.

So if both the US and Malaysian Governments couldn’t stem the fat tide in their respective countries, who can? I would say it’s still the government and we the people.

What we have is a terribly bloated public sector. The Star, quoting Prime Minister’s Office statistics, pointed out that at 1.4 million employees, it’s the largest civil service in South-East Asia.

Supersized and overweight. That’s a double whammy and the kind of Malaysian Book of Records we don’t need. So for a start, how about really downsizing the civil service? After all, why do we need so many civil servants to serve a population that’s way smaller than those in neighbouring countries like Indonesia, the Philippines and Thailand?

Next, I support calls to make it mandatory for civil servants to lose the fat and stay healthy. This is especially so for those who have yet to develop serious illnesses like diabetes. If need be, withhold promotions and salary increases if they don’t meet this KPI.

The reason why I am pushing for this is because civil servants get free medical services in government hospitals and clinics, even after retirement.

That’s a longstanding benefit which I don’t object to, since my retired police officer father is a beneficiary. But with a large, unhealthy government workforce, you can imagine the humongous medical bill we taxpayers are burdened with.

If nothing is done, it will become a bigger burden because, as doctors have warned, 20 years from now, those overweight and obese citizens will be suffering from all sorts of illnesses from stroke, heart disease and kidney failure to diabetes.

All that “will increase the health budget to an unsustainable level,” Malaysian Medical Association president Dr Ashok Zachariah Philip told The Star.

Thanks to my role as the primary caregiver to my elderly parents who suffer from various illnesses, I know how scarily expensive medical care can be for those without access to free treatments.

As a private sector employee, I am grateful to be working for a company that gives me good medical coverage. But I have also bought my own health insurance to prepare for the day when I retire and lose my safety net. In the meantime, I work at staying healthy and medication-free.

As I said, I do not begrudge the medical benefit for government servants. What I do begrudge are those who take it for granted, instead of taking responsibility for their own well-being.

If the Government can work on getting its workforce in shape, non-public sector citizens too can do their part by eating less and more healthily and getting off our butts.

Admittedly, it’s hard now to go out for a run or even a stroll because of the current heat wave and haze. But we can try taking the stairs instead of the lift, drink more water than teh tarik and yes, eat less of our beloved nasi lemak.

Proud as we are that Time magazine ranked it as the ninth healthiest breakfast in the world, we know better. A dish that tastes that good cannot be healthy!

I leave this thought with you: The OEDC report, which measures the personal and economic health of nations, found that the United States indeed topped the chart in personal wealth and even the number of rooms in American homes.

So yes, they have the wealth but where’s the health?


By June H.L. Wong
So Aunty, So What?

Aunty likes this quote by humourist Jarod Kintz: Obesity isn’t as cool as it used to be, back in the earlier centuries. Before it was a reflection on your gross income. Now it’s just gross. Feedback to aunty@thestar.com.my

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Tuesday, April 5, 2016

Putrajaya the obese-city! Address obesity urgently

Two men cycling in front of the Palace of justice in Putrajaya

Malaysia has the highest percentage of overweight people in South-East Asia and the bulk of them are in Putrajaya. A survey has found that two out of five Malaysian civil servants are obese. The news is not good for the country’s health.

KUALA LUMPUR: It has been long known that Malaysia is the fattest country in South-East Asia. Now, it has been proven that the administrative capital of Putrajaya has the highest rate of overweight and obese people in the country.

Findings from the 2015 National Health and Morbidity Survey (NHMS) placed Putrajaya as the city with the highest percentage of overweight, obese and abdominally obese people in the country.

The study also suggests that the administrative capital’s population has a 37% chance of being overweight, while the obesity rate stood at 43%.

Even more startling, the NHMS said government and semi-government employees took the cake as those struggling most with obesity, with a 40.3% rate.

This could mean two out of every five of Malaysia’s civil servants may be obese.

Malaysia’s civil service has 1.4 million employees, according to the Prime Minister’s Office, and is the largest civil service in South-East Asia.

Other obesity demographics pointed out in the survey were Indians (43.5%), married adults (33.8%) and those who only studied up to secondary school (32.1%).


The findings put the Government in a rather red-faced situation, as it works on reversing the climbing number of obese and overweight Malaysians.

“As the number of people with obesity increases, the nation now is facing an upward surge of non-communicable diseases such as diabetes and cardiovascular diseases,” the survey concluded, describing the Malaysian obesity epidemic as alarming.

Although a review of public health policy was not necessary now, it opined, the Government was asked to provide more supportive environments for Malaysians to lead healthier lifestyles.

Malaysian Medical Association (MMA) president Dr Ashok Zachariah Phillip agreed, saying that the life of a typical government servant did not afford them much time or money to stay healthy.

“If you look at the strata, it’s usually the lower grade workers who are overweight because it takes money to keep fit. Government workers go to work at 7am, come back at 7pm and have no time between work and family to even think of exercising,” he said.

It doesn’t help either that basic essentials like white rice, sugar and oil are staple Malaysian diets and are unhealthy, he said.

“For us doctors, this could be a real headache 20 years down the road. We are going to have a growing population with stroke and heart disease, and kidney failures that will increase the health budget at an unsustainable level,” he added.

The Government needs to look into setting up more gyms in agencies and dish out incentives for employees to fight the bulge.

Health Minister Datuk Seri Dr S. Subramaniam said the figures were worrying.

“I don’t think the people are in the best state of health,” he said.

He said general sedentary work has a correlation to obesity, a trend which government agencies, namely the police, were trying to counter.

“The police recognised this recently and have taken some effort to make sure they have lean policemen. They will try to take action to meet this target,” Dr Subramaniam said yesterday.

Malacca and Perlis are the states with second and third highest obesity rates. Sabah and the Federal Territory of Labuan were the slimmest states.

By Micholas Cheng The Star

Address obesity urgently




AMID the current heat wave, not only are we blue over the greens (The Star, April 4) with highland vegetables wilting and Ipoh’s famous pomelos shrinking in size, schoolchildren are also getting more obese with the sound advice from the authorities to stay indoors.

Presumably, many children will go in droves to air-conditioned malls and fast food restaurants for meals, which naturally will add to the problem of obesity.

Doctors say obesity is defined as the condition of being very overweight and having a body mass index, or BMI, of 30 or higher. The BMI is a measure of the weight relative to the height.

Evidently, obesity is manifested in the abdominal fat around the waist of children and adults as well.

But we should not get unduly worried with the adults because they are mature and knowledgeable enough to take responsibility for their health.

However, the innocent children’s health is undeniably our responsibility. Like it or not, we are accountable and answerable for the obesity problem in their adult life.

Today we can see the startling increase in the number of obese children across the country. Yet many parents unfortunately are seemingly too busy to check their children’s diet, let alone their daily exercise like the recommended walk of up to 10,000 steps a day.

Perhaps schools should voluntarily take up the task of creating awareness about the high risks and health hazards of obesity.

One practical way is to do routine short workouts: get students to burn calories by doing some exercises in the school assembly or in class every day – even some stretching exercises will suffice.

Certainly, this will increase their metabolic rate, thus strengthening their mental ability to learn; reducing levels of stress and depression; and suppressing the appetite.

When the heat wave is over, I would say it is the ethical and moral responsibility of the school authorities to bring back the Physical Standard Tests for all students like the good old days and mobilise all the staff to run selected athletic events such as the 100m, 200m, long jump, high jump and shot putt. Set certain standards for the events.

It would be much better if the Education Ministry’s Sports Department sets the national standards for all these events, which was done in the 60s till the 80s by using the co-curriculum 001 and 002 cards.

Next, it is also incumbent upon the Education Ministry to make it mandatory for school canteens to display the calorie counts for all the food so that the children will learn how to make healthy food choices and to calculate the total calorie intake they require for a day (about 1,600 and 2,500 calories per day depending on their age, gender and activity level).Eventually, they will “graduate” to become smart healthy consumers.

Let’s take these critical measures seriously to save our children from potential health risks like diabetes, high blood pressure, high cholesterol, heart disease and also some cancers.

This will invariably reduce the national health bill as well.

It was reported in “Putrajaya tops obese list” (see above) that we already have the highest percentage of overweight people in South-East Asia, and two out of five civil servants are obese.

Hence, invariably, the Government has to increase the health budget to cater for our increasingly ailing population if the obesity problem is not urgently addressed.

THOMAS KOK Ipoh

Related story: Healthy when young, healthy when old



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Monday, September 7, 2015

Scientists Finally Discover How the Obesity Gene Works



Scientists have finally figured out how the key gene tied to obesity makes people fat, a major discovery that could open the door to an entirely new approach to the problem beyond diet and exercise.

The work solves a big mystery: Since 2007, researchers have known that a gene called FTO was related to obesity, but they didn’t know how, and could not tie it to appetite or other known factors.

Now experiments reveal that a faulty version of the gene causes energy from food to be stored as fat rather than burned. Genetic tinkering in mice and on human cells in the lab suggests this can be reversed, giving hope that a drug or other treatment might be developed to do the same in people.

The work was led by scientists at MIT and Harvard University and published online Wednesday by the New England Journal of Medicine.

The discovery challenges the notion that “when people get obese it was basically their own choice because they choose to eat too much or not exercise,” said study leader Melina Claussnitzer, a genetics specialist at Harvard-affiliated Beth Israel Deaconess Medical Center. “For the first time, genetics has revealed a mechanism in obesity that was not really suspected before” and gives a third explanation or factor that’s involved.

Independent experts praised the discovery.

“It’s a big deal,” said Dr. Clifford Rosen, a scientist at Maine Medical Center Research Institute and an associate editor at the medical journal.

“A lot of people think the obesity epidemic is all about eating too much,” but our fat cells play a role in how food gets used, he said. With this discovery, “you now have a pathway for drugs that can make those fat cells work differently.”

Several obesity drugs are already on the market, but they are generally used for short-term weight loss and are aimed at the brain and appetite; they don’t directly target metabolism.

Researchers can’t guess how long it might take before a drug based on the new findings becomes available. But it’s unlikely it would be a magic pill that would enable people to eat anything they want without packing on the pounds. And targeting this fat pathway could affect other things, so a treatment would need rigorous testing to prove safe and effective.

The gene glitch doesn’t explain all obesity. It was found in 44 percent of Europeans but only 5 percent of blacks, so other genes clearly are at work, and food and exercise still matter.

Having the glitch doesn’t destine you to become obese but may predispose you to it. People with two faulty copies of the gene (one from Mom and one from Dad) weighed an average of 7 pounds more than those without them. But some were obviously a lot heavier than that, and even 7 pounds can be the difference between a healthy and an unhealthy weight, said Manolis Kellis, a professor at MIT.

Related: More U.S. Adults Are Now Obese than Overweight

He and Claussnitzer are seeking a patent related to the work. It was done on people in Europe, Sweden and Norway, and funded by the German Research Center for Environmental Health and others, including the U.S. National Institutes of Health.

Researchers can’t guess how long it might take before a drug based on the new findings becomes available. But it’s unlikely it would be a magic pill that would enable people to eat anything they want without packing on the pounds. And targeting this fat pathway could affect other things, so a treatment would need rigorous testing to prove safe and effective.

The gene glitch doesn’t explain all obesity. It was found in 44 percent of Europeans but only 5 percent of blacks, so other genes clearly are at work, and food and exercise still matter.

Having the glitch doesn’t destine you to become obese but may predispose you to it. People with two faulty copies of the gene (one from Mom and one from Dad) weighed an average of 7 pounds more than those without them. But some were obviously a lot heavier than that, and even 7 pounds can be the difference between a healthy and an unhealthy weight, said Manolis Kellis, a professor at MIT.

Related: ‘Healthy Obesity’ Turns Unhealthy Over Time

He and Claussnitzer are seeking a patent related to the work. It was done on people in Europe, Sweden and Norway, and funded by the German Research Center for Environmental Health and others, including the U.S. National Institutes of Health.

“It’s a potential target” for drug development, said Dr. Sam Klein, an obesity researcher at Washington University in St. Louis. He called the work “an amazing study” and “a scientific tour de force.”

Dr. Rudolph Leibel, an obesity expert at Columbia University in New York, used the same term — “tour de force.” Still, some earlier research suggests the FTO gene may influence other aspects of obesity such as behavior and appetite.

“It’s possible there are several mechanisms being affected,” and that fat-burning is not the whole story, he said.

Read This Next: There Are 6 Types Of Obesity — And Each Should Be Treated Differently

- Associated Press

Scientists Finally Discover How the Obesity Gene Works



Scientists have finally figured out how the key gene tied to obesity makes people fat, a major discovery that could open the door to an entirely new approach to the problem beyond diet and exercise.

The work solves a big mystery: Since 2007, researchers have known that a gene called FTO was related to obesity, but they didn’t know how, and could not tie it to appetite or other known factors.

Now experiments reveal that a faulty version of the gene causes energy from food to be stored as fat rather than burned. Genetic tinkering in mice and on human cells in the lab suggests this can be reversed, giving hope that a drug or other treatment might be developed to do the same in people.

The work was led by scientists at MIT and Harvard University and published online Wednesday by the New England Journal of Medicine.

The discovery challenges the notion that “when people get obese it was basically their own choice because they choose to eat too much or not exercise,” said study leader Melina Claussnitzer, a genetics specialist at Harvard-affiliated Beth Israel Deaconess Medical Center. “For the first time, genetics has revealed a mechanism in obesity that was not really suspected before” and gives a third explanation or factor that’s involved.

Independent experts praised the discovery.

“It’s a big deal,” said Dr. Clifford Rosen, a scientist at Maine Medical Center Research Institute and an associate editor at the medical journal.

“A lot of people think the obesity epidemic is all about eating too much,” but our fat cells play a role in how food gets used, he said. With this discovery, “you now have a pathway for drugs that can make those fat cells work differently.”

Several obesity drugs are already on the market, but they are generally used for short-term weight loss and are aimed at the brain and appetite; they don’t directly target metabolism.

Researchers can’t guess how long it might take before a drug based on the new findings becomes available. But it’s unlikely it would be a magic pill that would enable people to eat anything they want without packing on the pounds. And targeting this fat pathway could affect other things, so a treatment would need rigorous testing to prove safe and effective.

The gene glitch doesn’t explain all obesity. It was found in 44 percent of Europeans but only 5 percent of blacks, so other genes clearly are at work, and food and exercise still matter.

Having the glitch doesn’t destine you to become obese but may predispose you to it. People with two faulty copies of the gene (one from Mom and one from Dad) weighed an average of 7 pounds more than those without them. But some were obviously a lot heavier than that, and even 7 pounds can be the difference between a healthy and an unhealthy weight, said Manolis Kellis, a professor at MIT.

Related: More U.S. Adults Are Now Obese than Overweight

He and Claussnitzer are seeking a patent related to the work. It was done on people in Europe, Sweden and Norway, and funded by the German Research Center for Environmental Health and others, including the U.S. National Institutes of Health.

Researchers can’t guess how long it might take before a drug based on the new findings becomes available. But it’s unlikely it would be a magic pill that would enable people to eat anything they want without packing on the pounds. And targeting this fat pathway could affect other things, so a treatment would need rigorous testing to prove safe and effective.

The gene glitch doesn’t explain all obesity. It was found in 44 percent of Europeans but only 5 percent of blacks, so other genes clearly are at work, and food and exercise still matter.

Having the glitch doesn’t destine you to become obese but may predispose you to it. People with two faulty copies of the gene (one from Mom and one from Dad) weighed an average of 7 pounds more than those without them. But some were obviously a lot heavier than that, and even 7 pounds can be the difference between a healthy and an unhealthy weight, said Manolis Kellis, a professor at MIT.

Related: ‘Healthy Obesity’ Turns Unhealthy Over Time

He and Claussnitzer are seeking a patent related to the work. It was done on people in Europe, Sweden and Norway, and funded by the German Research Center for Environmental Health and others, including the U.S. National Institutes of Health.

“It’s a potential target” for drug development, said Dr. Sam Klein, an obesity researcher at Washington University in St. Louis. He called the work “an amazing study” and “a scientific tour de force.”

Dr. Rudolph Leibel, an obesity expert at Columbia University in New York, used the same term — “tour de force.” Still, some earlier research suggests the FTO gene may influence other aspects of obesity such as behavior and appetite.

“It’s possible there are several mechanisms being affected,” and that fat-burning is not the whole story, he said.

Read This Next: There Are 6 Types Of Obesity — And Each Should Be Treated Differently

- Associated Press